Guides

Written for the week the data does not look right

Short, sourced, and specific to movement disorder trials. Each guide answers the question in the first paragraph and cites the evidence below it.

Clinical development, biostatistics

Your early-phase fine-motor data came back variable. Here is why, and what to fix before the next study.

The six variance sources behind noisy Phase 1 and Phase 2 motor endpoints, how to tell which one you have, and what to change in the next protocol.

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Clinical operations, regulatory, procurement

Twelve questions to ask before adopting a digital motor endpoint

The FDA clinical outcome assessment framework, practice effects, how it runs alongside the rating scale, site burden, data provenance, integration, cost. Direct answers.

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Digital endpoint leads, medical directors

Digital motor endpoint options for movement disorder trials, compared

Clinician-rated scales, wearable accelerometry, smartphone active tests, device-agnostic platforms, and digitized spiral drawing: what each measures, what it demands of sites, and where the evidence stands.

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Sample size calculator

Compare rating-scale and kinematic effect sizes at your power and alpha.

Endpoint coverage comparison

Which motor domains each assessment measures, and where the gaps are.