Perspectives on CNS clinical measurement

Thought leadership on endpoint strategy, digital assessment technology, regulatory science, and the challenges of measuring treatment effects in the most complex organ system.

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Endpoint Strategy

Why CNS Clinical Trials Fail: The Measurement Problem Nobody Talks About

Most CNS trial failures are attributed to the drug. Often, it is the endpoint that failed first.

Digital Health

Digital Endpoints in Neurology: Beyond the Hype

Separating the promise from the reality of digital biomarkers in neurological clinical trials.

Clinical Development

The Case for Phase 1 Endpoint Strategy

Why the most impactful endpoint decisions happen before your first efficacy trial.

Data Integrity

Central Rater Committees: An Underappreciated Quality Control

How rater variability silently degrades your endpoint data, and what to do about it.

Technology

Quantifying Fine Motor Function: What Kinematic Data Reveals

A technical perspective on what 240Hz sampling and multidimensional kinematic capture can see that clinical scales cannot.

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